Trained as a pianist at the conservatoires of Bari, Geneva and London. Studied conducting at the Accademia Musicale Pescarese under Gilberto Serembe, took master-classes with Leonard Bernstein and Karl Österreicher, as well as at the University of Toronto under Michel Tabachnik, Pierre Hétu and Richard Bradshaw. From the late 90s the conductor’s career has been closely linked with Russian ensembles.
Currently Mastrangelo directs the St Petersburg Music Hall theatre and its orchestra Northern Symphony, is Principal Conductor of the Yakutia philharmonic orchestra Simphonica Artica, and is Principal Guest Conductorм of the Novosibirsk Academic Symphony Orchestra and the Novaya Opera theatre in Moscow. He also directs the festival Opera for All in St Petersburg and takes part in the TV show Grand Opera on the Kultura channel.
He made his debut at the Mariinsky Theatre in 2008 with the opera Tosca. Under the baton of Mastrangelo, there have also been performed such Verdi’s operas as Aida, Rigoletto, La traviata, La forza del destino, Simon Boccanegra and I vespri siciliani.
In 2013 he was awarded the order of the Star of Italy for his contribution to the development of cultural ties.